منابع مشابه
Oncogenes and anti-oncogenes in tumorigenesis.
Recent advances have led to the identification of cellular genes which are involved in the initiation and progression of tumorigenesis. The proto-oncogenes, which normally participate in the regulation of cell proliferation and differentiation, can become oncogenes through alterations in the regulation of their expression and/or their coding sequences. Their contribution to the tumorigenic phen...
متن کاملTransient oncogenes.
A given cancer is produced by a unique combination of genetic alterations that target specific genes, most often leading to activation of oncogenes and inactivation of tumor suppressor genes. Traditional oncogenes, such as RasV12, are involved in maintaining pro-survival and proliferation signals activated in the cell. Several evidences suggest that cancer cells are addicted to oncogenes and th...
متن کاملOncogenes in myeloproliferative disorders.
Myeloproliferative disorders (MPDs) constitute a group of hematopoietic malignancies that feature enhanced proliferation and survival of one or more myeloid lineage cells. William Dameshek is credited for introducing the term "MPDs" in 1951 when he used it to group chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) under one cl...
متن کاملOncogenes and radiation carcinogenesis.
Current research indicates a role for several oncogenes in radiation-induced carcinogenesis in vivo and cell transformation in vitro. Certain oncogenes are probably also involved in some cases of human cancer caused by exposure to nonionizing radiation and may play a mechanistic role in the phenomenon of radioresistance seen in later stages of tumor progression. The mechanisms of oncogene activ...
متن کاملDarwin's gemmules and oncogenes.
In a recent issue of Annals of Oncology, Purushotham and Sullivan [1] reviewed Darwin’s legacy to cancer and medicine. However, they did not discuss Darwin’s Pangenesis, which provides a novel mechanism for cancerometastasis. Darwin habitually thought big. But the cell theory allowed him to think small. He wrote The Origin of Species without any reference to cellular structure in animals and pl...
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ژورنال
عنوان ژورنال: Journal of Clinical Otolaryngology Head and Neck Surgery
سال: 1996
ISSN: 1225-0244,2713-833X
DOI: 10.35420/jcohns.1996.7.1.1